Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets

نویسندگان

  • Prashant S. Kharkar
  • Hariprasad Vankayalapati
  • Evans Coutinho
  • Vijay Gokhale
چکیده

Out-of-the-box approaches are currently needed to replenish the souring pipelines of pharmaceutical companies across the globe. Here a theme is presented - the use of central nervous system (CNS) drugs as leads for non-CNS targets. The approach is related to the use of existing drugs for new indications. Suitable chemical modifications of the CNS drugs abolish their CNS penetration. These novel analogs may then be screened for activity against non-CNS targets. Careful selection of the appropriate structural modifications remains the key to success.

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2014